PubMed LRB

• Response to 'Decision to reject screening for familial hypercholesterolaemia is flawed' by Wald and Martin 17 octobre 2021
  No abstract
  David S Wald
• Contextualising courtship: Exploring male body odour effects on vocal modulation 16 octobre 2021
  Voice characteristics are important to communicate socially relevant information. Recent research has shown that individuals alter their voices depending on the context of social interactions and perceived characteristics of the audience, and this affects how they are perceived. Numerous studies have also shown that the presence of bodily odours can elicit psychological changes in people. […]
  Juan David Leongómez
• Cardiometabolic Disorders and the Risk of Critical COVID-19 as Compared to Influenza Pneumonia 13 octobre 2021
  We aimed to compare the influence of cardiometabolic disorders on the incidence of severe COVID-19 vs. non-COVID pneumonia. We included all consecutive patients admitted with SARS-CoV-2-positive pneumonia between 12 March 2020 and 1 April 2020 and compared them to patients with influenza pneumonia hospitalized between December 2017 and December 2019 at the same tertiary hospital […]
  Antoine Fayol
• Diuretic vs. placebo in intermediate-risk acute pulmonary embolism: a randomized clinical trial 11 octobre 2021
  CONCLUSION: In normotensive patients with intermediate-risk PE, a single bolus of furosemide improved the primary efficacy outcome at 24 h and maintained stable renal function. In the furosemide group, urine output increased, without a demonstrable improvement in heart rate, systolic blood pressure, or arterial oxygenation.ClinicalTrials.gov identifier NCT02268903.
  Pascal Lim
• Rivaroxaban versus Dalteparin in Cancer-Associated Thromboembolism: A Randomized Trial 10 octobre 2021
  BACKGROUND: Direct oral anticoagulants (DOACs) are an alternative to low-molecular-weight heparin for treating cancer-associated venous thromboembolism (VTE).
  Benjamin Planquette
• Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota 8 octobre 2021
  In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted […]
  Basma A Ahmed
• Elevated Circulating Stem Cells Level is Observed One Month After Implantation of Carmat Bioprosthetic Total Artificial Heart 8 octobre 2021
  The Aeson® total artificial heart (A-TAH) has been developed as a total heart replacement for patients at risk of death from biventricular failure. We previously described endothelialization of the hybrid membrane inside A-TAH probably at the origin of acquired hemocompatibility. We aimed to quantify vasculogenic stem cells in peripheral blood of patients with long-term A-TAH […]
  Léa Guyonnet
• Gonadotropins as novel active partners in vascular diseases: insight from angiogenic properties and thrombotic potential of endothelial colony-forming cells 8 octobre 2021
  CONCLUSION: Gonadotropins increase ECFC-related angiogenesis and may be involved in thrombin generation in cardiovascular disease. Gonadotropins may act as biomarkers; moreover, we hypothesize that gonadotropin blocking strategies may be a novel interesting therapeutic approach in atherosclerotic cardiovascular disease.
  Grégoire Détriché
• Transverse sinus stenting without surgical repair in idiopathic CSF rhinorrhea associated with transverse sinus stenoses: a pilot study 8 octobre 2021
  CONCLUSIONS: According to the authors' results, venous sinus stenting may result in the disappearance of the leak in many cases of idiopathic CSF rhinorrhea. Larger comparative studies are needed to assess the efficiency and safety of venous stenting as a first-line approach in patients with spontaneous CSF rhinorrhea associated with transverse sinus stenoses.
  Stephanie Lenck
• Anterior interhemispheric approach for anterior fossa dural arteriovenous fistulas 7 octobre 2021
  Anterior fossa dural arteriovenous fistulas (AF-DAVF) usually display a cortical venous drainage and are therefore at risk for rupture. Microsurgery is traditionally considered in many centers as the first-line treatment since endovascular treatment (EVT) entails a lower cure rate and significant ophthalmic risks. The anterior interhemispheric approach (AIA), originally described by Mayfrank in 1996, seems […]
  Etienne Lefevre
• Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak 6 octobre 2021
  CONCLUSIONS: Our findings support an activation loop in the skin in CLL associated with endothelial alteration and immune infiltration of cytotoxic and type I IFN-polarized cells leading to clinical manifestations.
  L Frumholtz
• Live-Cell Probe for In Situ Single-Cell Monitoring of Mitochondrial DNA Methylation 29 septembre 2021
  Mitochondria, as the center of energy production, play an important role in cell homeostasis by regulating the cellular metabolism and mediating the cellular response to stress. Epigenetic changes such as DNA and histone methylation have been increasingly recognized to play a significant role in homeostasis and stress response. The cross-talking between the metabolome and the […]
  Han Zhao
• Evaluation of Signaling Pathways Profiling in Human Dermal Endothelial Cells Treated by Snake Venom Cysteine-Rich Secretory Proteins (svCRiSPs) from North American Snakes Using Reverse Phase Protein Array (RPPA) 26 septembre 2021
  Cysteine-Rich Secretory Proteins (CRiSPs) are typically found in many snake venoms; however, the role that these toxins play in the pathophysiology of snakebites is still unclear. Herein, we compared the effects of snake venom CRiSPs (svCRiSPs) from the most medically important species of North American snakes on endothelial cell permeability and vascular permeability. We used […]
  Montamas Suntravat
• Reduced-dose intravenous thrombolysis for acute intermediate high-risk pulmonary embolism: Rationale and design of the PEITHO-3 trial 24 septembre 2021
  Intermediate high-risk pulmonary embolism (PE) is characterised by right ventricular (RV) dysfunction and elevated circulating cardiac troponin levels despite apparent haemodynamic stability at presentation. In these patients, full-dose systemic thrombolysis reduced the risk of haemodynamic decompensation or death but increased the risk of life-threatening bleeding. Reduced-dose thrombolysis may be capable of improving safety while maintaining […]
  Olivier Sanchez
• Thrombus of the Aorta and SARS-CoV-2 Infection: Cause or Trigger? 23 septembre 2021
  Objective: Coronavirus disease 19 is a well-established cause of rare arterial thrombosis. Nevertheless, the exact mechanism of arterial thrombosis remains to be elucidated. We herein report the case of a large floating thrombus of the aortic arch, its surgical management and histological analysis. Case: A 65-year-old patient presented to the emergency department with a suspected […]
  Guillaume Goudot
• First-In-Human Phase I Study of a Next-Generation, Oral, Transforming Growth Factor-Beta Receptor 1 Inhibitor, LY3200882 in Patients with Advanced Cancer 22 septembre 2021
  CONCLUSIONS: LY3200882 as monotherapy and combination therapy was safe and well tolerated with preliminary antitumor activity observed in PC. Further studies to evaluate the efficacy of LY3200882 with gemcitabine and nab-paclitaxel in advanced PC are warranted.
  Timothy A Yap
• Daily Telephone Call During the COVID-19 Pandemic: Perceptions of Families and Providers 22 septembre 2021
  CONCLUSION: Fixed-time, daily telephone calls in the ICU allowed satisfactory transmission of information between physicians and surrogate decision makers, as perceived by both parties. However, the telephone-based communication strategy could still be improved.
  Caroline Fritz
• Cardiothoracic Surgery Training Program Director Awareness of Available Visiting Medical Student Clerkships for the Underrepresented in Medicine 20 septembre 2021
  A diversity gap exists within cardiothoracic (CT) surgery that might be addressed with currently available medical student pipeline programs. We sought to assess CT surgery residency/fellowship program directors' (PD) awareness of and participation in underrepresented in medicine visiting medical student clerkship programs (UIM-VMSCPs). We reviewed the ACGME program finder database and medical school websites to […]
  Angelica C Martin
• Reductive elimination of [AlH₂]⁺ from a cationic Ga-Al dihydride 16 septembre 2021
  Oxidative addition of TMEDA-supported [AlH(2)]^(+) to [{BDI}Ga] (BDI = {HC(C(CH(3))N(2,6-iPr(2)-C(6)H(3)))(2)}) provides [{BDI}Ga(H)-Al(H)(tmeda)][B(C(6)H(3)-3,5-Me(2))(4)] (TMEDA = N,N,N'N'-tetramethylethylenediamine) with a covalent metal-metal bond. The reaction is readily reversed by substituting TMEDA for an N-heterocyclic carbene or dissolving in THF.
  Louis J Morris
• Spinal metastases from thyroid cancer: Some prognostic factors 10 septembre 2021
  CONCLUSION: For cases presenting SpM from TC, we highlighted that the only prognostic factors were the progression of the cancer (ECOG-PS) and the clinical neurological impact of the SpM (Frankel status). Surgery should be discussed mainly for stabilization and neurological decompression.
  Alexia Planty-Bonjour