PubMed LRB

• Are spine metastasis survival scoring systems outdated and do they underestimate life expectancy? Caution in surgical recommendation guidance 23 juillet 2021
  CONCLUSIONS: The use of prognostic scoring systems in the estimation of survival in patients with SPM has become obsolete and therefore underestimates survival. Surgical treatment decisions should no longer be based on survival estimations alone but must also take into account patient symptoms, spinal instability, and quality of life.
  Gaston Tabourel
• Author Correction: Cardiovascular, hematological and neurosensory impact of COVID-19 and variants 21 juillet 2021
  Correction to: European Review for Medical and Pharmacological Sciences 2021; 25 (8): 3350-3364-DOI: 10.26355/eurrev_202104_25747-PMID: 33928623, published online 30 April, 2021. After publication, the authors requested to correct the Acknowledgements of the above-mentioned article. There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/25747.
  J C Chachques
• Quality of life in patients with pulmonary embolism treated with edoxaban versus warfarin 19 juillet 2021
  CONCLUSION: Our findings indicate that patients with an index PE treated with edoxaban or warfarin have a similar long-term QoL. Since our study was a follow-up study from a well-controlled clinical trial setting, future studies should be designed in a daily clinical practice setting. We suggest a longitudinal design for investigation of changes in QoL […]
  Roisin Bavalia
• Platelet activation in critically ill COVID-19 patients 17 juillet 2021
  CONCLUSION: We provide evidence that platelets contribute to COVID-19 severity. Plasma sP-selectin level was associated with severity and in-hospital mortality. Transcriptional analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation. These findings provide additional evidence for platelet activation in driving critical COVID-19. Specific studies evaluating the performance of these biomarkers are required.
  Nader Yatim
• Paediatric headbox as aerosol and droplet barrier 16 juillet 2021
  CONCLUSION: A HEP-filter modified headbox may serve as an effective droplet and aerosol barrier adjunct for the protection of staff caring for children receiving HFNO.
  Monica Sahih
• A trivalent TNF-R2 as a new tumor necrosis factor alpha-blocking molecule 12 juillet 2021
  The neutralization of tumor necrosis factor alpha (TNFα) with biopharmaceuticals is a successful therapy for inflammatory diseases. Currently, one of the main TNFα-antagonists is Etanercept, a dimeric TNF-R2 ectodomain. Considering that TNFα and its receptors are homotrimers, we proposed that a trimeric TNF-R2 ectodomain could be an innovative TNFα-antagonist. Here, the 3cTNFR2 protein was designed […]
  María A Contreras
• Response 11 juillet 2021
  No abstract
  Charles Tacquard
• Antimicrobial prophylaxis in noninstrumented spine surgery: a prospective study to determine efficacy and drawbacks 9 juillet 2021
  CONCLUSIONS: A single dose of preoperative cefazolin is effective and mandatory in preventing surgical site infections in NISS. Single-dose antibiotic prophylaxis has an immediate impact on cutaneous flora by increasing cefazolin-resistant bacteria.
  Aymeric Amelot
• When could airway plateau pressure above 30 cmH₂O be acceptable in ARDS patients? 8 juillet 2021
  No abstract
  Jean-Luc Diehl
• Subarachnoid-pleural fistula: To drain or not to drain 8 juillet 2021
  Subarachnoid-pleural fistula (SPF) is a rare complication of spine surgery with a transthoracic approach. The outcome of such an injury is affected by not only the pulmonary status due to the pleural effusion but also the neurological one, secondary to the intracranial hypotension. After reviewing the few published cases of SPF, the journey to diagnosis […]
  E Moncomble
• Expression and characterization of a novel single-chain anti-vascular endothelial growth factor antibody in the goat milk 5 juillet 2021
  Vascular endothelial growth factor (VEGF) has essential functions in angiogenesis, endothelial cell proliferation, migration, and tumor invasion. Different approaches have been developed to suppress tumor angiogenesis, which is considered a hallmark of cancer. Anti-VEGF monoclonal antibodies constitute an important strategy for cancer immunotherapy, which has been produced on several platforms. In this study, a novel […]
  María J Leiva
• Comparison of Fibrin Monomers and D-dimers to predict thrombotic events in critically ill patients with COVID-19 pneumonia: A retrospective study 5 juillet 2021
  No abstract
  Alexandre Godon
• Severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A prospective French multicenter cohort 5 juillet 2021
  CONCLUSIONS: Severe PH-COPD is characterized by moderate airway obstruction but marked dyspnea and marked hypoxemia, low DLCO and high mPAP. This phenotype is associated with poor prognosis.
  Gaëlle Dauriat
• Design and characterization of a novel dimeric blood-brain barrier penetrating TNFα inhibitor 5 juillet 2021
  Tumor necrosis factor-alpha (TNFα) inhibitors could prevent neurological disorders systemically, but their design generally relies on molecules unable to cross the blood-brain barrier (BBB). This research was aimed to design and characterize a novel TNFα inhibitor based on the angiopeptide-2 as a BBB shuttle molecule fused to the extracellular domain of human TNFα receptor 2 […]
  Viana Manrique-Suárez
• How to deal with an unexpected event that could alter the normal activity of cellular therapy? Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) 3 juillet 2021
  The SARS-CoV-2 (COVID-19) pandemic has rapidly impacted cell therapy activities across the globe. Not only was this, unexpected event, a threat to patients who had previously received hematopoietic cell transplantation or other cell therapy such as CAR-T cells, but also, it was responsible for a disruption of cell therapy activities due to the danger of […]
  Jacques Olivier Bay
• Cubic Nanoparticles for Magnetic Hyperthermia: Process Optimization and Potential Industrial Implementation 2 juillet 2021
  Cubic nanoparticles are referred to as the best shaped particles for magnetic hyperthermia applications. In this work, the best set of values for obtaining optimized shape and size of magnetic particles (namely: reagents quantities and proportions, type of solvents, temperature, etc.) is determined. A full industrial implementation study is also performed, including production system design […]
  Omar Sánchez Sánchez
• Transpulmonary Pressure-Guided Invasive Ventilation in Morbidly Obese Patients: Another Brick in the Wall of Personalized Medicine 2 juillet 2021
  No abstract
  Jean-Luc Diehl
• Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis 1 juillet 2021
  No abstract
  Li Li
• Anti-inflammatory Activity of the Protein Z-Dependent Protease Inhibitor 30 juin 2021
  The protein Z (PZ)-dependent plasma protease inhibitor (ZPI) is a glycoprotein that inhibits factor XIa and, in the presence of PZ, FXa. Recently, ZPI has been shown to be an acute-phase protein (APP). As usually APPs downregulate the harmful effects of inflammation, we tested whether ZPI could modulate the increase of cytokines observed in inflammatory […]
  Mahita Razanakolona
• COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects 29 juin 2021
  Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with vascular inflammation and endothelial injury. Severe forms of SARS-CoV-2 infection induce acute respiratory distress syndrome (ARDS) and there is still an ongoing debate on whether COVID-19 ARDS and its perfusion defect differs from ARDS […]
  David M Smadja