PubMed LRB

• Lupus anticoagulant single positivity at acute phase is not associated with venous thromboembolism or in-hospital mortality in COVID-19 21 avril 2021
  CONCLUSIONS: COVID-19 patients have an increased prevalence of LA positivity associated with biological inflammation markers. However, positive LA at admission is not associated with VTE risk and/or in-hospital mortality.
  Nicolas Gendron
• Chronic use of Renin-Angiotensin-Aldosterone-System blockers and mortality in COVID-19: a multicenter prospective cohort and literature review 20 avril 2021
  CONCLUSION: Our results do not support previous concerns regarding these drugs, nor a potential protective effect as reported in previous poorly designed studies and metanalyses. RAAS blockers should not be discontinued during the pandemic, while in-hospital management of these drugs will be clarified by randomized trials. NCT04262921.
  Nathalie Gault
• Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping 19 avril 2021
  The mechanism of increased postprandial nonesterified fatty acid (NEFA) appearance in the circulation in impaired glucose tolerance (IGT) is due to increased adipose tissue lipolysis but could also be contributed to by reduced adipose tissue (AT) dietary fatty acid (DFA) trapping and increased 'spillover' into the circulation. Thirty-one subjects with IGT (14 women, 17 men) […]
  Émilie Montastier
• Vaccination against COVID-19: insight from arterial and venous thrombosis occurrence using data from VigiBase 17 avril 2021
  No abstract
  David M Smadja
• Treatment of cancer associated thrombosis. 2019 update of the French guidelines 16 avril 2021
  No abstract
  I Mahé
• Impact of a shared decision-making mHealth tool on caregivers' team situational awareness, communication effectiveness, and performance during pediatric cardiopulmonary resuscitation: study protocol of a cluster randomized controlled trial 14 avril 2021
  BACKGROUND: Effective team communication, coordination, and situational awareness (SA) by team members are critical components to deliver optimal cardiopulmonary resuscitation (CPR). Complexity of care during CPR, involvement of numerous providers, miscommunication, and other exogenous factors can all contribute to negatively influencing patient care, thus jeopardizing survival. We aim to investigate whether an mHealth supportive tool […]
  Frédéric Ehrler
• Perioperative hemodynamic optimization: from guidelines to implementation-an experts' opinion paper 14 avril 2021
  Despite a large body of evidence, the implementation of guidelines on hemodynamic optimization and goal-directed therapy remains limited in daily routine practice. To facilitate/accelerate this implementation, a panel of experts in the field proposes an approach based on six relevant questions/answers that are frequently mentioned by clinicians, using a critical appraisal of the literature and […]
  Jean-Luc Fellahi
• Role of VAMP7-dependent secretion of reticulon 3 in neurite growth 14 avril 2021
  No abstract
  José Wojnacki
• D-dimer at hospital admission for COVID-19 are associated with in-hospital mortality, independent of venous thromboembolism: Insights from a French multicenter cohort study 13 avril 2021
  CONCLUSIONS: D-dimer concentration>1128ng/mL is a relevant predictive factor for in-hospital mortality in patients hospitalised for COVID-19 in a medical ward, regardless of the occurrence of venous thromboembolism during hospitalisation.
  Richard Chocron
• IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19 11 avril 2021
  CONCLUSIONS: Higher serum levels of IL-6 and IL-10 are associated with the severity of the disease and a higher comorbidity index among adults aged 65 and over with COVID-19. This should raise awareness of the importance of comorbidity index, rather than age, during risk stratification.
  Rafael Luís Luporini
• Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality 8 avril 2021
  CONCLUSION: Angiogenic factor PlGF is a relevant predictive factor for in-hospital mortality in COVID-19 patients. More than a biomarker, we hypothesize that PlGF blocking strategies could be a new interesting therapeutic approach in COVID-19.
  David M Smadja
• Evaluation of mid-term (6-12 months) neurotoxicity in B-cell lymphoma patients treated with CAR T-cells: a prospective cohort study 6 avril 2021
  CONCLUSION: In this cohort of patients treated with CD19-targeted CAR-T cells , we found no evidence for neurological or cognitive toxicity, 6 and 12 months after treatment.
  Didier Maillet
• Applications of Melanin and Melanin-Like Nanoparticles in Cancer Therapy: A Review of Recent Advances 3 avril 2021
  Thanks to the growing knowledge about cancers and their interactions with the immune system, a huge number of therapeutic cancer vaccines have been developed in the past two decades. Despite encouraging results in pre-clinical models, cancer vaccines have not yet achieved significant clinical efficacy. Several factors may contribute to such poor results, including the difficulty […]
  Stefania Cuzzubbo
• Intraoperative Ultrasound Shear-Wave Elastography in Focal Cortical Dysplasia Surgery 3 avril 2021
  Previous studies reported interest in intraoperative shear-wave elastography (SWE) guidance for brain-tumor and epilepsy surgeries. Focal cortical dysplasia (FCD) surgery is one of the most appropriate indications for using SWE guidance. The aim of this study was to evaluate the efficacy of ultrasound SWE techniques for the intraoperative detection of FCDs. We retrospectively analyzed data […]
  Bertrand Mathon
• Examination of the Efficacy and Cross-Reactivity of a Novel Polyclonal Antibody Targeting the Disintegrin Domain in SVMPs to Neutralize Snake Venom 3 avril 2021
  Snake envenomation can result in hemorrhage, local necrosis, swelling, and if not treated properly can lead to adverse systemic effects such as coagulopathy, nephrotoxicity, neurotoxicity, and cardiotoxicity, which can result in death. As such, snake venom metalloproteinases (SVMPs) and disintegrins are two toxic components that contribute to hemorrhage and interfere with the hemostatic system. Administration […]
  Shelby S Szteiter
• Anticoagulation in COVID-19: not strong for too long? 2 avril 2021
  No abstract
  Charles Tacquard
• C-N and C-H Activation of an N-Heterocyclic Carbene by Magnesium(II) Hydride and Magnesium(I) Complexes 1 avril 2021
  Reactions of the hindered N-heterocyclic carbene, :C{(MesNCH)(2)} (IMes; Mes = mesityl), with a series of β-diketiminatomagnesium(II) hydride and dimagnesium(I) complexes were carried out at 80 °C. The reactions involving the magnesium hydrides, [{(^(Ar)Nacnac)Mg(μ-H)}(2)] [^(Ar)Nacnac = [(ArNCMe)(2)CH]^(-), where Ar = 2,6-diethylphenyl (Dep) or 2,6-diisopropylphenyl (Dip)], proceeded via activation of an exocyclic C-N bond of IMes, giving […]
  K Yuvaraj
• Emergency CABG for a migrated stent in a COVID-19 positive patient 26 mars 2021
  Percutaneous coronary interventions (PCI) have become a standard of treatment worldwide. Despite high safety rates, iatrogenic complications caused by stent dislodgements do exist in 0.21% of cases and most require emergency coronary artery by-pass grafting (CABG). Here we present a case of a coronavirus disease 2019 positive 40-year-old male patient presenting with STEMI due to […]
  Juan F Parra
• Outpatient vagus nerve stimulation surgery in patients with drug-resistant epilepsy with severe intellectual disability 26 mars 2021
  CONCLUSION: Our study highlights the safety and feasibility of VNS surgery in an outpatient setting for patients with severe intellectual disability. We report detailed protocol and preoperative checklist to optimize outpatient VNS surgery in these not able-bodied patients. Severe disabilities or epilepsy-associated handicaps should not be an exclusion criterion when considering ambulatory VNS implantation.
  Insafe Mezjan
• Use of ADAM-C and CHA2DS2-VASc scores to predict complex aortic atheroma after brain ischemia: A prospective observational study 25 mars 2021
  BACKGROUND AND AIMS: Complex aortic atheroma (CAA) is a common cause of acute brain ischemia (BI), including ischemic stroke (IS) and transient ischemic attack (TIA), and is associated with recurrence. The CHA2DS2-VASc score is a useful tool for predicting stroke in patients with atrial fibrillation (AF), and can also predict cardiovascular events in other populations, […]
  Florence Nicot