PubMed LRB

• Treatment of cancer associated thrombosis 22 janvier 2022
  In active cancers, venous thromboembolism is a poor prognosis factor and one of the main causes of death. Venous thromboembolism is 4 to 7 times more common in patients with active cancer compared with the general population. The risk of thrombosis depends on characteristics related to the patient, cancer, and current treatments. The management of […]
  Raphaël Hindré
• A review of European guidelines for patient blood management with a particular emphasis on antifibrinolytic drug administration for cardiac surgery 22 janvier 2022
  The concept of patient blood management (PBM) was introduced by the World Health Organization in 2011 and is defined as a "patient-focused, evidence-based and systematic approach for optimizing the management of patients and transfusion of blood products to ensure high quality and effective patient care". Patient blood management is a multimodal approach based on three […]
  Andrew Klein
• DeepImageTranslator: A free, user-friendly graphical interface for image translation using deep-learning and its applications in 3D CT image analysis 21 janvier 2022
  The advent of deep-learning has set new standards in an array of image translation applications. At present, the use of these methods often requires computer programming experience. Non-commercial programs with graphical interface usually do not allow users to fully customize their deep-learning pipeline. Therefore, our primary objective is to provide a simple graphical interface that […]
  Run Zhou Ye
• Effects of Extra-Long-Acting Recombinant Bovine FSH (bscrFSH) on Cattle Superovulation 20 janvier 2022
  Over the last few years, several commercial FSH products have been developed for cattle superovulation (SOV) purposes in Multiple Ovulation and Embryo Transfer (MOET) programs. The SOV response is highly variable among individuals and remains one of the main limiting factors in obtaining a profitable number of transferable embryos. In this study, follicle stimulating hormone […]
  Miguel A Gutiérrez-Reinoso
• Lives of Violence and Vengeance: Life Stories of Older Oaxacan Adults 19 janvier 2022
  This qualitative research identifies and analyzes emotions linked to affective experiences and cultural aspects of experiences of violence in 219 older adults of eight Indigenous groups in Oaxaca, Mexico. Life stories are examined from perspectives of cultural gerontology, anthropology of emotions and critical medical anthropology with a gender perspective. Family violence, structural violence in daily […]
  Douglas C Nance
• The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage 12 janvier 2022
  The transcription factor hepatocyte nuclear factor 4 A (HNF4A) controls the metabolic features of several endodermal epithelia. Both HNF4A and HNF4G are redundant in the intestine and it remains unclear whether HNF4A alone controls intestinal lipid metabolism. Here we show that intestinal HNF4A is not required for intestinal lipid metabolism per se, but unexpectedly influences […]
  Romain Girard
• Recent Advances in Anticoagulant Treatment of Immune Thrombosis: A Focus on Direct Oral Anticoagulants in Heparin-Induced Thrombocytopenia and Anti-Phospholipid Syndrome 11 janvier 2022
  For more than 10 years, direct oral anticoagulants (DOACs) have been increasingly prescribed for the prevention and treatment of thrombotic events. However, their use in immunothrombotic disorders, namely heparin-induced thrombocytopenia (HIT) and antiphospholipid syndrome (APS), is still under investigation. The prothrombotic state resulting from the autoimmune mechanism, multicellular activation, and platelet count decrease, constitutes similarities […]
  Julie Carré
• Plasma ratio of angiopoietin-2 to angiopoietin-1 is a biomarker of vascular impairment in chronic obstructive pulmonary disease patients 11 janvier 2022
  Chronic obstructive pulmonary disease (COPD) patients have an increased risk of cardiovascular disease. Muscle biopsies have revealed that the muscle vasculature in COPD patients was characterized by a capillary rarefaction with reduced pericyte coverage. Thus, an imbalance of the plasma Angiopoietin-1 / Angiopoietin-2 (Ang2/Ang1) ratio could constitute a non-invasive marker of the muscle vascular impairment. […]
  Fares Gouzi
• Development and application of novel BiFC probes for cell sorting based on epigenetic modification 10 janvier 2022
  The epigenetic signature of cancer cells varies with disease progression and drug treatment, necessitating the study of these modifications with single cell resolution over time. The rapid detection and sorting of cells based on their underlying epigenetic modifications by flow cytometry can enable single cell measurement and tracking to understand tumor heterogeneity and progression warranting […]
  Agnes Mendonca
• Lead exposure induces dysregulation of constitutive heterochromatin hallmarks in live cells 10 janvier 2022
  Lead (Pb) is a heavy metal contaminant commonly found in air, soil, and drinking water due to legacy uses. Excretion of ingested Pb can result in extensive kidney damages due to elevated oxidative stress. Epigenetic alterations induced by exposure to Pb have also been implied but remain poorly understood. In this work, we assessed changes […]
  Oscar F Sánchez
• Using different multivariate approaches to assess water quality of qanats in arid zones of Southern Central Mexico 9 janvier 2022
  Qanats in the aquifer of the Tehuacán Valley (Mexico) represent an ancient way of using groundwater that is still practiced today. They are used mainly for agricultural irrigation. However, anthropogenic activities have jeopardized the use of these aquifers. We analyzed 24 qanats in the Tehuacán Valley to assess water quality. Based on 24 physicochemical variables, […]
  Jacinto Elías Sedeño-Díaz
• Brain Biopsy for Neurological Diseases of Unknown Etiology in Critically Ill Patients: Feasibility, Safety, and Diagnostic Yield 7 janvier 2022
  CONCLUSIONS: Brain biopsy in critically ill patients with neurologic disease of unknown etiology is associated with high diagnostic yield, therapeutic modifications and postbiopsy survival advantage. Safety profile seems acceptable in most patients. The benefit/risk ratio of brain biopsy in this population should be carefully weighted.
  Bertrand Mathon
• What level of D-dimers can safely exclude pulmonary embolism in COVID-19 patients presenting to the emergency department? 7 janvier 2022
  CONCLUSION: The same D-Dimer thresholds as those validated in non-COVID outpatients should be used to safely rule out PE.
  Marie-Pierre Revel
• Low-dose corticosteroid therapy for cardiogenic shock in adults (COCCA): study protocol for a randomized controlled trial 4 janvier 2022
  BACKGROUND: Cardiogenic shock (CS) is a life-threatening condition characterized by circulatory insufficiency caused by an acute dysfunction of the heart pump. The pathophysiological approach to CS has recently been enriched by the tissue consequences of low flow, including inflammation, endothelial dysfunction, and alteration of the hypothalamic-pituitary-adrenal axis. The aim of the present trial is to […]
  Armand Mekontso Dessap
• Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study 4 janvier 2022
  We previously identified matrix metalloproteinase 2 (MMP2) and MMP9 plasma levels as candidate biomarkers of bevacizumab activity in patients with recurrent glioblastoma. The aim of this study was to assess the predictive value of MMP2 and MMP9 in a randomized phase III trial in patients with newly diagnosed glioblastoma and to explore their tumor source. […]
  Carine Jiguet-Jiglaire
• Regional anaesthesia in patients on antithrombotic drugs: Joint ESAIC/ESRA guidelines 4 janvier 2022
  CONCLUSION: In patients taking antiplatelet or anticoagulant medications, practitioners must consider the bleeding risk both before and after nerve blockade and during insertion or removal of a catheter. Healthcare teams managing such patients must be aware of the risk and be competent in detecting and managing any possible haematomas.
  Sibylle Kietaibl
• Outcome of Temporary Circulatory Support As a Bridge-to-Left Ventricular Assist Device Strategy in Cardiogenic Shock Patients 2 janvier 2022
  CONCLUSIONS: BTL strategy is not associated with a lower survival among cardiogenic shock patients with LVAD implantation. Predictors of mortality are combined surgery with LVAD, higher BMI, and HF duration.
  Auriane Bidaut
• Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry 30 décembre 2021
  Introduction: Optimizing patient safety and quality improvement is increasingly important in surgery. Benchmarks and clinical quality registries are being developed to assess the best achievable results for several surgical procedures and reduce unwarranted variation between different centers. However, there is no clinical database from international centers for establishing standardized reference values of patients undergoing surgery […]
  Richard Drexler
• Examining the entire delayed respiratory syncytial virus season in Western Australia 21 décembre 2021
  No abstract
  David Anthony Foley
• A Brønsted Acidic Gallium Hydride: Facile Interconversion of NNNN-Macrocycle Supported [GaI]+ and [GaIIIH]2 21 décembre 2021
  Protonolysis of [Cp*M] (M = Ga, In, Tl) with [(Me4TACD)H][BAr4Me] (Me4TACD = N,N',N'',N'''-tetramethyl-1,4,7,10-tetraazacyclododecane; [BAr4Me]- = [B{C6H3-3,5-(CH3)2}4]-) provided monovalent salts [(Me4TACD)M][BAr4Me], whereas [Cp*Al]4 yielded trivalent [(Me4TACD)AlH][BAr4Me]2. Protonation of [(Me4TACD)Ga][BAr4Me] with [Et3NH][BAr4Me] gave an unusually acidic (pKa(CH3CN) = 24.5) gallium(III) hydride dication [(Me4TACD)GaH][BAr4Me]2: deprotonation with IMe4 (1,3,4,5-tetramethyl-imidazol-ylidene)...
  Louis J Morris