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Severity of endothelial dysfunction is associated with the occurrence of hemorrhagic complications in COPD patients treated by extracorporeal CO2 removal – Laboratoire de recherches biochirurgicales à Paris 15ème

Severity of endothelial dysfunction is associated with the occurrence of hemorrhagic complications in COPD patients treated by extracorporeal CO2 removal

Jean‑Luc Diehl 1,2* , Jean Loup Augy 1 , Nadia Rivet 2,3, Coralie Guerin 2,4, Richard Chocron 5,6 and David M. Smadja 2,3

Abstract :
In chronic obstructive pulmonary disease (COPD) patients extracorporeal CO2 removal (ECCO2R) has been associated with both hemorrhagic and thrombotic complications [1], which could be related to an endothelial dysfunction promoted in part by extracorporeal life support [2]. Moreover, endothelial dysfunction is a hallmark of severe COPD: an imbalance between repair capacity and endothelial damage has been reported in stable patients [3], with a changing profle during acute exacerbations [4]. We planned to rigorously study these points using a formalized ECCO2R register (NCT02965079) combined with a study project (Hector: Hemostasis and ECCO2R).

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Severity of endothelial dysfunction is associated with the occurrence of hemorrhagic complications in COPD patients treated by extracorporeal CO2 removal.

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