Stem Cells Therapeutic Applications – Chapter 11 – David M.Smadja

Mariusz Z. Ratajczak Stem Cell Institute at James Graham Brown Cancer Center University of Louisville Louisville, KY, USA.

It is obvious that stem cells and regenerative medicine have become the “hottest” contemporary scientific topics, covered by many scientific journals, textbooks, and public media. Therefore, in order to remain highly competitive and abreast with new developments, this new book should help students and researchers to better reflect and update the broadened scope of the field. There have been proposed different types of stem cells for therapeutic applications. However, with the exception of hematopoietic stem cells (HSCs) for hematological applications, the current clinical results with other types of stem cells are somewhat disappointing.
Hematopoietic stem cells (HSCs) isolated from hematopoietic tissues have been successfully employed for 50 years in hematological transplantations to treat leukemia, lymphomas, bone marrow aplasia, and some cases of immunodeficiency as well as metabolic disorders. The successful clinical application of HSCs has helped to establish the rationale for the development of stem cell therapies and regenerative medicine, and regenerative medicine is still looking for a pluripotent/multipotent stem cell, more primitive in development than HSC, that will be able to differentiate across germ layers into cells belonging to meso-, ecto-, and endoderm and be safely employed without unwanted side effects in therapy. There have been proposed some solutions to this problem by employing embryonic stem cells (ESCs) derived from fertilized embryos or created by nuclear transfer and induced pluripotent stem cells (iPSCs) obtained by genetic modification of adult postnatal cells. Nevertheless, the potential applications of the more primitive embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) in the clinic have so far been discouraging as both these types of stem cells have exhibited several problems, including genomic instability, a risk of teratoma formation, and the possibility of rejection…

Stem Cells Therapeutic Applications

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